TRANSCENDENT: Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments.

Reference List

1. Ontario Neurotrauma Foundation. Concussion Advisory Subcommittee of the Ontario Neurotrauma Foundation. Standards for Post-concussion Care: From Diagnosis to the Interdisciplinary. 8 June 2017 Concussion clinic. Available at:

2. D’Lauro C, Jones ER, Swope LM, Anderson MN, Broglio S, Schmidt JD. Under-representation of female athletes in research informing influential concussion consensus and position statements: an evidence review and synthesis. Br J Sports Med [Internet]. 2022 Jul 18;bjsports-2021-105045. Available from:

3. Foley T, Vale L. A framework for understanding, designing, developing and evaluating learning health systems. Learn Heal Syst [Internet]. 2022 May 20;n/a(n/a):e10315. Available from:

4. Broglio SP, Kontos AP, Levin H, Schneider K, Wilde EA, Cantu RC, et al. National Institute of Neurological Disorders and Stroke and Department of Defense Sport-Related Concussion Common Data Elements Version 1.0 Recommendations. J Neurotrauma. 2018 Jul;neu.2018.5643.

5. Reed N, Zemek R, Dawson J, Ledoux AAA, Provvidenza C, Paniccia M, et al. Living guideline for pediatric concussion care [Internet]. PedsConcussion. 2021. Available from:

6. Ledoux AA, Barrowman N, Bijelić V, Borghese MM, Davis A, Reid S, et al. Is early activity resumption after paediatric concussion safe and does it reduce symptom burden at 2 weeks post injury? The Pediatric Concussion Assessment of Rest and Exertion (PedCARE) multicentre randomised clinical trial. Br J Sports Med. 2021 Nov;56(5):271–8.

7. Ledoux AA, Barrowman NJ, Boutis K, Davis A, Reid S, Sangha G, et al. Multicentre, randomised clinical trial of paediatric concussion assessment of rest and exertion (PedCARE): a study to determine when to resume physical activities following concussion in children. Br J Sports Med. 2019 Feb;53(3).

8. Gravel J, Ledoux AA, Tang K, Yeates KO, Craig W, Osmond M, et al. Early versus delayed emergency department presentation following mild Traumatic Brain Injury and the presence of symptom at 1, 4 and 12 weeks in children. Emerg Med J. 2020;

9. Yeates KO, Tang K, Barrowman N, Freedman SB, Gravel J, Gagnon I, et al. Derivation and Initial Validation of Clinical Phenotypes of Children Presenting with Concussion Acutely in the Emergency Department: Latent Class Analysis of a Multi-Center, Prospective Cohort, Observational Study. J Neurotrauma. 2019;36(11):1758–67.

10. Cairncross M, Yeates KO, Tang K, Madigan S, Beauchamp M, Craig W, et al. Association of early post-injury screen time with concussion recovery in children: An A-CAP study. Submitt Pediatr. 2022;

11. Munia TTK, Haider A, Schneider C, Romanick M, Fazel-Rezai R. A Novel EEG Based Spectral Analysis of Persistent Brain Function Alteration in Athletes with Concussion History. Sci Rep [Internet]. 2017;7(1):1–13. Available from:

12. Leddy JJ, Hinds AL, Miecznikowski J, Darling S, Matuszak J, Baker JG, et al. Safety and prognostic utility of provocative exercise testing in acutely concussed adolescents: A randomized trial. Clin J Sport Med. 2018;28(1):13–20.

13. Nadir HM, Adam C, Scott D, N SH, S FM, K JR, et al. Derivation of the Buffalo Concussion Physical Examination risk of delayed recovery (RDR) score to identify children at risk for persistent postconcussive symptoms. Br J Sports Med. 2021;

14. Haider MN, Leddy JJ, Du W, J Macfarlane A, Viera KB, Willer BS. Practical Management: Brief Physical Examination for Sport-Related Concussion in the Outpatient Setting. Clin J Sport Med Off J Can Acad Sport Med. 2020 Sep;30(5):513–7.

15. Cowan K, Osmond M, et al. Concussion Priority Setting Partnership [Internet]. James Lind Alliance. 2022. Available from:

16. Feinberg C, Carr C, Zemek R, Yeates KO, Master C, Schneider K, et al. Association of Pharmacological Interventions With Symptom Burden Reduction in Patients With Mild Traumatic Brain Injury: A Systematic Review. JAMA Neurol. 2021 May;78(5):596–608.

17. Mannix R, Levy R, Zemek R, Yeates KO, Arbogast K, Meehan WP, et al. Fluid Biomarkers of Pediatric Mild Traumatic Brain Injury: A Systematic Review. J Neurotrauma. 2020 Jun 2;

18. Zemek R, Barrowman N, Freedman SB, Gravel J, Gagnon I, Mcgahern C, et al. Clinical risk score for persistent postconcussion symptoms among children with acute concussion in the ED. JAMA. 2016 Mar 8;315(10):1014–25.

19. Ledoux AAA, Tang K, Yeates KO, Pusic M V., Boutis K, Craig WR, et al. Natural Progression of Symptom Change and Recovery From Concussion in a Pediatric Population. JAMA Pediatr [Internet]. 2019 Jan 7;173(1):e183820. Available from:

20. Silverberg ND, Iaccarino MA, Panenka WJ, Iverson GL, McCulloch KL, Dams-O’Connor K, et al. Management of Concussion and Mild Traumatic Brain Injury: A Synthesis of Practice Guidelines. Vol. 101, Archives of Physical Medicine and Rehabilitation. W.B. Saunders; 2020. p. 382–93.

21. Silverberg ND, Iverson GL. Expert Panel Survey to Update the American Congress of Rehabilitation Medicine Definition of Mild Traumatic Brain Injury. Arch Phys Med Rehabil. 2021 Jan;102(1):76–86.

22. Schneider KJ, Patricios J, Echemendia RJ, Makdissi M, Davis GA, Ahmed OH, et al. Concussion in sport: the consensus process continues. Br J Sports Med [Internet]. 2022 May 6;bjsports-2022-105673. Available from:

23. Marshall S, Bayley M, McCullagh S, Berrigan L, Fischer L, Ouchterlony D, et al. Guideline for Concussion/Mild Traumatic Brain Injury (mTBI) and Prolonged Symptoms (3rd edition, 2018) [Internet]. Ontario Neurotrauma Foundation. 2018. Available from:

24. Briffa T, Symons T, Zeps N, Straiton N, Tarnow-Mordi WO, Simes J, et al. Normalising comparative effectiveness trials as clinical practice. Trials [Internet]. 2021;22(1):620. Available from:

25. Zemek R, Osmond MH, Barrowman N. Predicting and preventing postconcussive problems in paediatrics (5P) study: protocol for a prospective multicentre clinical prediction rule derivation study in children with concussion. BMJ Open. 2013 Aug;3(8).

26. Grool AM, Aglipay M, Momoli F, Meehan WP, Freedman SB, Yeates KO, et al. Association Between Early Participation in Physical Activity Following Acute Concussion and Persistent Postconcussive Symptoms in Children and Adolescents. JAMA [Internet]. 2016 Dec 20;316(23):2504–14. Available from:

27. Lyons TW, Mannix R, Tang K, Yeates KO, Sangha G, Burns EC, et al. Paediatric post-concussive symptoms: symptom clusters and clinical phenotypes. Br J Sports Med. 2022 Jul;56(14):785–91.

28. Zhang C, Tang K, Zemek R, Beauchamp M, Craig W, Doan Q, et al. Factor structure and measurement invariance of post-concussion symptom ratings on the Health and Behaviour Inventory across time, raters, and groups: An A-CAP study. J Int Neuropsychol Soc. 2022;1–14.

29. Boutis K, Gravel J, Freedman SB, Craig W, Tang K, DeMatteo CA, et al. The Diagnosis of Concussion in Pediatric Emergency Departments: A Prospective Multicenter Study. J Emerg Med [Internet]. 2018 Jun;54(6):757–65. Available from:

30. Grool AM, Aglipay M, Momoli F, Meehan WP, Freedman SB, Yeates KO, et al. Association Between Early Participation in Physical Activity Following Acute Concussion and Persistent Postconcussive Symptoms in Children and Adolescents. Jama [Internet]. 2016;316(23):2504. Available from:

31. Leddy JJ, Haider MN, Ellis MJ, Mannix R, Darling SR, Freitas MS, et al. Early Subthreshold Aerobic Exercise for Sport-Related Concussion: A Randomized Clinical Trial. JAMA Pediatr. 2019;173(4):319–25.

32. Hicks SD, Leddy J, Lichak BP, Onks C, Dretsch M, Tennant P, et al. Defining Biological Phenotypes of Mild Traumatic Brain Injury Using Saliva MicroRNA Profiles. J Neurotrauma. 2022 Jul;39(13–14):923–34.

33. Howell DR, Brilliant AN, Storey EP, Podolak OE, Meehan WP 3rd, Master CL. Objective Eye Tracking Deficits Following Concussion for Youth Seen in a Sports Medicine Setting. J Child Neurol. 2018 Oct;33(12):794–800.

34. Schneider KJ, Nettel-Aguirre A, Palacios-Derflingher L, Mrazik M, Brooks BL, Woollings K, et al. Concussion Burden, Recovery, and Risk Factors in Elite Youth Ice Hockey Players. Clin J Sport Med Off J Can Acad Sport Med. 2021 Jan;31(1):70–7.

35. Schneider KJ, Meeuwisse WH, Palacios-Derflingher L, Emery CA. Changes in Measures of Cervical Spine Function, Vestibulo-ocular Reflex, Dynamic Balance, and Divided Attention Following Sport-Related Concussion in Elite Youth Ice Hockey Players. J Orthop Sport Phys Ther [Internet]. 2018 Dec;48(12):974–81. Available from:

36. Schneider KJ, Meeuwisse WH, Nettel-Aguirre A, Barlow K, Boyd L, Kang J, et al. Cervicovestibular rehabilitation in sport-related concussion: a randomised controlled trial. Br J Sports Med. 2014 Sep;48(17):1294–8.

37. Institute of Medicine (US) Roundtable on Evidence-Based Medicine; Olsen LA, Aisner D, McGinnis JM, editors. The Learning Healthcare System: Workshop Summary. Washington (DC): National Academies Press (US); 2007. Appendix D, IOM Roundtable on Evidence-Base.

38. Lavis J, Reed R, Bullock H, Wodchis W, Hayes A. Rapid Synthesis Creating a Rapid-learning Health System in Ontario 31 March 2018. [Internet]. McMaster Health Forum. Available from:

39. Brookhart MA, Rassen JA, Schneeweiss S. Instrumental variable methods in comparative safety and effectiveness research. Pharmacoepidemiol Drug Saf. 2010 Jun;19(6):537–54.

40. Varner C, Thompson C, de Wit K, Borgundvaag B, Houston R, McLeod S. Predictors of persistent concussion symptoms in adults with acute mild traumatic brain injury presenting to the emergency department. CJEM. 2021 May;23(3):365–73.

41. Booker J, Sinha S, Choudhari K, Dawson J, Singh R. Predicting functional recovery after mild traumatic brain injury: the SHEFBIT cohort. Brain Inj. 2019;33(9):1158–64.

42. Canadian Institute of Health Research. Gender-Based Analysis Plus (GBA+) at CIHR [Internet]. 2022. Available from:

43. Walker WC, Franke LM, McDonald SD, Sima AP, Keyser-Marcus L. Prevalence of mental health conditions after military blast exposure, their co-occurrence, and their relation to mild traumatic brain injury. Brain Inj. 2015;29(13–14):1581–8.

44. Ledoux, A., Webster, R.J., Clarker, A.E., Fell, DB., Knight, B.D., Gardner, W., Cloutier, P., Gray, C., Tuna, M., and Zemek R. Risk of Mental Health Problems in Children and Youth Following Concussion. JAMA Netw Open. 2022;In Press(3):1–13.

45. Dijkers MP, Hart T, Tsaousides T, Whyte J, Zanca JM. Treatment Taxonomy for Rehabilitation: Past, Present, and Prospects. Arch Phys Med Rehabil [Internet]. 2014;95(1, Supplement):S6–16. Available from:

46. Vaccarino AL, Dharsee M, Strother S, Aldridge D, Arnott SR, Behan B, et al. Brain-CODE: A Secure Neuroinformatics Platform for Management, Federation, Sharing and Analysis of Multi-Dimensional Neuroscience Data. Front Neuroinform. 2018;12:28.

47. Means MJ, Myers RK, Master CL, Arbogast KB, Fein JA, Corwin DJ. Assault-Related Concussion in a Pediatric Population. Pediatr Emerg Care [Internet]. 2022;38(9). Available from:

48. Sicard V, Brown O, Butterfield L, Al. E. Acceptability, Usability, and Credibility of an Early Mindfulness-Based Intervention Delivered via a Mobile App for Pediatric Concussion. Abstracts of the 2nd Annual Meeting of the Canadian Concussion Network/Réseau Canadien des Commotions (CCN-RCC). J Head Trauma Rehabil [Internet]. 2022 Sep;37(5):E390–427. Available from:

49. Kerr ZY, Chandran A, Nedimyer AK, Arakkal A, Pierpoint LA, Zuckerman SL. Concussion Incidence and Trends in 20 High School Sports. Pediatrics. 2019 Nov 1;144(5).

50. Mollayeva, Tatyana, El-Khechen-Richandi G, Colantonio A. “Sex & gender considerations in concussion research.” Concussion. 2018;3(3 CNC51).

51. Sicard V, Moore RD, Ellemberg D. Long-term cognitive outcomes in male and female athletes following sport-related concussions. Int J Psychophysiol Off J Int Organ Psychophysiol. 2018 Oct;132(Pt A):3–8.

52. Canada S. Postal Code OM Conversion File Plus (PCCF+) Version 6C, Reference Guide. Ottawa, Minister of Industry. 2016.). Available at:

53. Kralj B. Measuring Rurality – RIO2008_BASIC: Methodology and Results Toronto, Ontario: Ontario Medical Association, 2009, p. 20.

54. James Lind Alliance Priority Setting Partnerships.

55. Howell DR, Zemek R, Brilliant AN, Mannix RC, Master CL, Meehan WP 3rd. Identifying Persistent Postconcussion Symptom Risk in a Pediatric Sports Medicine Clinic. Am J Sports Med. 2018 Nov;46(13):3254–61.

56. Ledoux AA, Tang K, Gagnon I, Osmond MH, Yeates KO, Healey K, et al. Association Between Preinjury Symptoms and Postconcussion Symptoms at 4 Weeks in Youth. J Head Trauma Rehabil [Internet]. 2022;37(2). Available from:

57. Gravel J, Boutis K, Tang K, Beauchamp MH, Freedman SB, Dubrovsky AS, et al. Association between ondansetron use and symptom persistence in children with concussions: A 5P substudy. Can J Emerg Med. 2019;21(2):204–10.

58. Novak Z, Aglipay M, Barrowman N, Yeates KO, Beauchamp MH, Gravel J, et al. Association of persistent postconcussion symptoms with pediatric quality of life. JAMA Pediatr. 2016;170(12):1–8.

59. Rochefort C, Walters-Stewart C, Aglipay M, Barrowman N, Zemek R, Sveistrup H. Self-reported balance status is not a reliable indicator of balance performance in adolescents at one-month post-concussion. J Sci Med Sport [Internet]. 2017;20(11):970–5. Available from:

60. Post A, Hoshizaki TB, Zemek R, Gilchrist MD, Koncan D, Dawson L, et al. Pediatric concussion: biomechanical differences between outcomes of transient and persistent (> 4 weeks) postconcussion symptoms. J Neurosurg Pediatr. 2017 Jun;19(6):641–51.

61. Rochefort C, Walters-Stewart C, Aglipay M, Barrowman N, Zemek R, Sveistrup H. Balance markers in adolescents at 1 month postconcussion. Orthop J Sport Med. 2017;5(3):1–7.

62. Pediatric Emergency Research Canada (PERC) 5P Concussion Team. A comparison in a youth population between those with and without a history of concussion using biomechanical reconstruction. J Neurosurg Pediatr. 2017 Apr;19(4):502–10.

63. Zemek RL, Grool AM, Rodriguez Duque D, DeMatteo C, Rothman L, Benchimol EI, et al. Annual and Seasonal Trends in Ambulatory Visits for Pediatric Concussion in Ontario between 2003 and 2013. J Pediatr [Internet]. 2017;181:222-228.e2. Available from:

64. Mutch, W. Alan C. Ellis, Michael J. Ryner, Lawrence N. Graham, Ruth. Dufault, Brenden. Gregson, Brian. Hall, Thomas. Bunge, Martin. Essig M. Brain magnetic resonance imaging CO2 stress testing in adolescent post-concussion syndrome: pCASL findings. J Neurosurg [Internet]. 2015;125(September):1–13. Available from:

65. Maas AIR, Menon DK, Adelson PD, Andelic N, Bell MJ, Belli A, et al. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol [Internet]. 2017 Dec 1;16(12):987–1048. Available from:

66. Choe M, Rosenbaum P, Meyer B, Johnson C, Arbogast K, Browd S, et al. Building the Four Corners Youth Consortium (4CYC) for Brain Health in Youth Sports and Recreation (P5.218). Neurology [Internet]. 2017 Apr 18;88(16 Supplement):P5.218. Available from:

67. Silverberg ND, Otamendi T, Brasher PMA, Brubacher JR, Li LC, Lizotte PP, et al. Effectiveness of a guideline implementation tool for supporting management of mental health complications after mild traumatic brain injury in primary care: protocol for a randomised controlled trial. BMJ Open [Internet]. 2022 Jun 1;12(6):e062527. Available from:

68. Purkayastha S, Stokes M, Bell KR. Autonomic nervous system dysfunction in mild traumatic brain injury: a review of related pathophysiology and symptoms. Brain Inj. 2019;33(9):1129–36.

69. Pertab JL, Merkley TL, Cramond AJ, Cramond K, Paxton H, Wu T. Concussion and the autonomic nervous system: An introduction to the field and the results of a systematic review. NeuroRehabilitation. 2018;42(4):397–427.

70. Davis GA, Purcell L, Schneider KJ, Yeates KO, Gioia GA, Anderson V, et al. The Child Sport Concussion Assessment Tool 5th Edition (Child SCAT5): Background and rationale. Br J Sports Med. 2017 Jun;51(11):859–61.

71. Leddy J, Lesh K, Haider MN, Czuczman N, Baker JG, Miecznikowski J, et al. Derivation of a focused, brief concussion physical examination for adolescents with sport-related concussion. Clin J Sport Med. 2018 Oct 29;

72. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606–13.

73. Spitzer RL, Kroenke K, Williams JBW, Löwe B. A brief measure for assessing generalized anxiety disorder: The GAD-7. Arch Intern Med. 2006 May;166(10):1092–7.

74. Wilkinson MD, Dumontier M, Aalbersberg IjJ, Appleton G, Axton M, Baak A, et al. The FAIR Guiding Principles for scientific data management and stewardship. Sci Data [Internet]. 2016;3(1):160018. Available from:

75. Yeates KO, Beauchamp M, Craig W, Doan Q, Zemek R, Bjornson B, et al. Advancing Concussion Assessment in Pediatrics (A-CAP): a prospective, concurrent cohort, longitudinal study of mild traumatic brain injury in children: protocol study. BMJ Open. 2017 Jul;7(7):e017012.

76. Ledoux AA, Barrowman N, Bijelić V, Borghese MM, Davis A, Reid S, et al. Is early activity resumption after paediatric concussion safe and does it reduce symptom burden at 2 weeks post injury? The Pediatric Concussion Assessment of Rest and Exertion (PedCARE) multicentre randomised clinical trial. Br J Sports Med. 2021 Nov;0:1–8.

77. Abelson J, Li K, Wilson G, Shields K, Schneider C, Boesveld S. Supporting quality public and patient engagement in health system organizations: development and usability testing of the Public and Patient Engagement Evaluation Tool. Heal Expect an Int J public Particip Heal care Heal policy. 2016 Aug;19(4):817–27.

78. Hickling A, Mallory KD, Wilson KE, Del Fernandes R, Fuselli P, Reed N. The youth concussion awareness network (You-CAN) – a school-based peer-led intervention to improve concussion reporting and social support: the protocol for a cluster randomized trial. BMC Public Health. 2020 Feb;20(1):186.

79. Howell DR, Seehusen CN, Carry PM, Walker GA, Reinking SE, Wilson JC. An 8-Week Neuromuscular Training Program After Concussion Reduces 1-Year Subsequent Injury Risk: A Randomized Clinical Trial. Am J Sports Med. 2022 Mar;50(4):1120–9.

80. Howell DR, Seehusen CN, Walker GA, Reinking S, Wilson JC. Neuromuscular training after concussion to improve motor and psychosocial outcomes: A feasibility trial. Phys Ther Sport Off J Assoc Chart Physiother Sport Med. 2021 Nov;52:132–9.

81. Howell DR, Wingerson MJ, Kirkwood MW, Grubenhoff JA, Wilson JC. Early aerobic exercise among adolescents at moderate/high risk for persistent post-concussion symptoms: A pilot randomized clinical trial. Phys Ther Sport Off J Assoc Chart Physiother Sport Med. 2022 May;55:196–204.

82. Howell DR, Hunt DL, Aaron SE, Meehan WP 3rd, Tan CO. Influence of Aerobic Exercise Volume on Postconcussion Symptoms. Am J Sports Med. 2021 Jun;49(7):1912–20.

83. Howell DR, Hunt DL, Oldham JR, Aaron SE, Meehan WP 3rd, Tan CO. Postconcussion Exercise Volume Associations With Depression, Anxiety, and Dizziness Symptoms, and Postural Stability: Preliminary Findings. J Head Trauma Rehabil. 2022;37(4):249–57.

84. Howell DR, Myer GD, Brilliant A, Barber Foss K, Meehan WP 3rd. Quantitative Multimodal Assessment of Concussion Recovery in Youth Athletes. Clin J Sport Med Off J Can Acad Sport Med. 2021 Mar;31(2):133–8.

85. Howell DR, Osternig LR, Chou LS. Return to activity after concussion affects dual-task gait balance control recovery. Med Sci Sports Exerc. 2015;47(4):673–80.

86. Berkner J, Meehan WP 3rd, Master CL, Howell DR. Gait and Quiet-Stance Performance Among Adolescents After Concussion-Symptom Resolution. J Athl Train. 2017 Dec;52(12):1089–95.

87. Howell DR, Buckley TA, Lynall RC, Meehan WP. Worsening Dual-Task Gait Costs after Concussion and their Association with Subsequent Sport-Related Injury. J Neurotrauma [Internet]. 2018 Jul 15;35(14):1630–6. Available from:

88. Howell DR, Bonnette S, Diekfuss JA, Grooms DR, Myer GD, Wilson JC, et al. Dual-Task Gait Stability after Concussion and Subsequent Injury: An Exploratory Investigation. Sensors (Basel). 2020 Nov;20(21).

89. Howell DR, Osternig LR, Chou LS. Detection of Acute and Long-Term Effects of Concussion: Dual-Task Gait Balance Control Versus Computerized Neurocognitive Test. Arch Phys Med Rehabil. 2018 Jul;99(7):1318–24.

90. Howell DR, Osternig LR, Koester MC, Chou LS. The effect of cognitive task complexity on gait stability in adolescents following concussion. Exp Brain Res [Internet]. 2014 Jun 15 [cited 2018 May 11];232(6):1773–82. Available from:

91. Howell DR, Myer GD, Grooms D, Diekfuss J, Yuan W, Meehan WP 3rd. Examining Motor Tasks of Differing Complexity After Concussion in Adolescents. Arch Phys Med Rehabil [Internet]. 2019 Apr;100(4):613–9. Available from:

92. Howell DR, Lugade V, Taksir M, Meehan WP 3rd. Determining the utility of a smartphone-based gait evaluation for possible use in concussion management. Phys Sportsmed. 2020 Feb;48(1):75–80.

93. Howell DR, Lugade V, Potter MN, Walker G, Wilson JC. A multifaceted and clinically viable paradigm to quantify postural control impairments among adolescents with concussion. Physiol Meas. 2019 Sep 2;40(8).

94. Howell DR, Seehusen CN, Wingerson MJ, Wilson JC, Lynall RC, Lugade V. Reliability and Minimal Detectable Change for a Smartphone-Based Motor-Cognitive Assessment: Implications for Concussion Management. J Appl Biomech. 2021 Aug;37(4):380–7.

95. Roby PR, Metzger KB, McDonald CC, Corwin DJ, Huber CM, Patton DA, et al. Pre- and post-season visio-vestibular function in healthy adolescent athletes. Phys Sportsmed. 2021 Sep;1–9.

96. Master CL, Bacal D, Grady MF, Hertle R, Shah AS, Strominger M, et al. Vision and Concussion: Symptoms, Signs, Evaluation, and Treatment. Pediatrics. 2022 Aug;150(2).

97. Master CL, Bacal D, Grady MF, Hertle R, Shah AS, Strominger M, et al. Evaluation of the Visual System by the Primary Care Provider Following Concussion. Pediatrics. 2022 Aug;150(2).

98. Master CL, Podolak OE, Ciuffreda KJ, Metzger KB, Joshi NR, McDonald CC, et al. Utility of Pupillary Light Reflex Metrics as a Physiologic Biomarker for Adolescent Sport-Related Concussion. JAMA Ophthalmol. 2020 Nov;138(11):1135–41.

99. Scheiman M, Grady MF, Jenewein E, Shoge R, Podolak OE, Howell DH, et al. Frequency of oculomotor disorders in adolescents 11 to 17 years of age with concussion, 4 to 12 weeks post injury. Vision Res. 2021 Jun;183:73–80.

100. Alvarez TL, Yaramothu C, Scheiman M, Goodman A, Cotter SA, Huang K, et al. Disparity vergence differences between typically occurring and concussion-related convergence insufficiency pediatric patients. Vision Res. 2021 Aug;185:58–67.

101. Master CL, Scheiman M, Gallaway M, Goodman A, Robinson RL, Master SR, et al. Vision Diagnoses Are Common after Concussion in Adolescents. Clin Pediatr (Phila). 2016;55(3):260–7.

102. Storey EP, Master SR, Lockyer JE, Podolak OE, Grady MF, Master CL. Near Point of Convergence after Concussion in Children. Optom Vis Sci. 2017;94(1):96–100.

103. Master CL, Master SR, Wiebe DJ, Storey EP, Lockyer JE, Podolak OE, et al. Vision and Vestibular System Dysfunction Predicts Prolonged Concussion Recovery in Children. Clin J Sport Med Off J Can Acad Sport Med. 2018 Mar;28(2):139–45.

104. Mayer AR, Wertz C, Ryman SG, Storey EP, Park G, Phillips J, et al. Neurosensory Deficits Vary as a Function of Point of Care in Pediatric Mild Traumatic Brain Injury. J Neurotrauma. 2018 May;35(10):1178–84.

105. Storey EP, Wiebe DJ, DʼAlonzo BA, Nixon-Cave K, Jackson-Coty J, Goodman AM, et al. Vestibular rehabilitation is associated with visuovestibular improvement in pediatric concussion. J Neurol Phys Ther. 2018 Jul;42(3):134–41.

106. Desai N, Wiebe DJ, Corwin DJ, Lockyer JE, Grady MF, Master CL. Factors Affecting Recovery Trajectories in Pediatric Female Concussion. Clin J Sport Med Off J Can Acad Sport Med. 2019 Sep;29(5):361–7.

107. Master CL, Curry AE, Pfeiffer MR, Metzger KB, Kessler RS, Haarbauer-Krupa J, et al. Characteristics of Concussion in Elementary School-Aged Children: Implications for Clinical Management. J Pediatr. 2020 Aug;223:128–35.

108. Jain D, Arbogast KB, McDonald CC, Podolak OE, Margulies SS, Metzger KB, et al. Eye Tracking Metrics Differences among Uninjured Adolescents and Those with Acute or Persistent Post-Concussion Symptoms. Optom Vis Sci Off Publ Am Acad Optom. 2022 Aug;99(8):616–25.

109. Oldham JR, Master CL, Walker GA, Meehan WP 3rd, Howell DR. The Association between Baseline Eye Tracking Performance and Concussion Assessments in High School Football Players. Optom Vis Sci Off Publ Am Acad Optom. 2021 Jul;98(7):826–32.

110. Howell DR, Brilliant AN, Master CL, Meehan WP 3rd. Reliability of Objective Eye-Tracking Measures Among Healthy Adolescent Athletes. Clin J Sport Med Off J Can Acad Sport Med. 2020 Sep;30(5):444–50.

111. Bin Zahid A, Hubbard ME, Lockyer J, Podolak O, Dammavalam VM, Grady M, et al. Eye Tracking as a Biomarker for Concussion in Children. Clin J Sport Med Off J Can Acad Sport Med. 2020 Sep;30(5):433–43.

112. Healey K, Fang Z, Smith A, Zemek R, Ledoux AA. Altered Brain Network Functional Connectivity One Month Following Pediatric Concussion. SSRN Electron J [Internet]. 2022;Published. Available from:

113. Kardish R, Fang Z, Healey K, Al. E. Longitudinal analysis of perfusion in pediatric concussion. From acute to chronic phase. Abstracts of the 2nd Annual Meeting of the Canadian Concussion Network/Réseau Canadien des Commotions (CCN-RCC). J Head Trauma Rehabil [Internet]. 2022 Sep;37(5):E390–427. Available from:

114. Brown O, Healey K, Fang Z, Zemek R, Smith A, Ledoux A. Associations Between Psychological Resilience and Metrics of White Matter Microstructure in Pediatric Concussion. Peer Rev. 2022;

115. Al-Jebrni AH, Chwyl B, Wang XY, Wong A, Saab BJ. AI-enabled remote and objective quantification of stress at scale. Biomed Signal Process Control [Internet]. 2020;59:101929. Available from:

116. Chwyl B, Chung AG, Amelard R, Deglint J, Clausi DA, Wong A. SAPPHIRE: Stochastically acquired photoplethysmogram for heart rate inference in realistic environments. In: 2016 IEEE International Conference on Image Processing (ICIP). 2016. p. 1230–4.

117. Chwyl B, Chung A, Amelard R, Deglint J, Clausi D, Wong A. Time-Frequency Domain Analysis via Pulselets for Non-contact Heart Rate Estimation from Remotely Acquired Photoplethysmograms. In: 2016 13th Conference on Computer and Robot Vision (CRV). IEEE; 2016:201-207. doi:10.1109/CRV.2016.45.

118. Chwyl B, Amelard R, Clausi D, Wong A. A Bayesian Multi-Scale Framework for Photoplethysmogram Imaging Waveform Processing. J Comput Vis Imaging Syst [Internet]. 2016;2(1). Available from:

119. Leddy J, Master C, Mannix R, Wiebe D, Grady M, Meehan W, et al. Early targeted heart rate aerobic exercise versus placebo stretching for sport-related concussion in adolescents: a randomised controlled trial. Lancet Child Adolesc Heal. 2021;

120. McCrory P, Meeuwisse WH, Aubry M, Cantu B, Dvorák J, Echemendia RJ, et al. Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012. Br J Sports Med. 2013 Apr;47(5):250–8.

121. Thomas DG, Apps JN, Hoffmann RG, McCrea M, Hammeke T. Benefits of strict rest after acute concussion: A randomized controlled trial. Pediatrics. 2015;135(2):213–23.

122. Leddy J, Hinds A, Sirica D, Willer B. The Role of Controlled Exercise in Concussion Management. PM R. 2016 Mar;8(3 Suppl):S91–100.

123. Leddy JJ, Baker JG, Willer B. Active Rehabilitation of Concussion and Post-concussion Syndrome. Phys Med Rehabil Clin N Am. 2016 May;27(2):437–54.

124. Hunt AW, Laupacis D, Kawaguchi E, Greenspoon D, Reed N. Key ingredients to an active rehabilitation programme post-concussion: perspectives of youth and parents. Brain Inj [Internet]. 2018;32(12):1534–40. Available from:

125. Shore J, Hutchison MG, Nalder E, Reed N, Hunt A. Tele-Active Rehabilitation for adolescents with concussion: a feasibility study. BMJ open Sport Exerc Med. 2022;8(1):e001277.

126. Hunt AW, Agnihotri S, Sack L, Tint A, Greenspoon D, Gauvin-Lepage J, et al. Mood-related changes in children and adolescents with persistent concussion symptoms following a six-week active rehabilitation program. Brain Inj. 2020 Jul;34(8):1068–73.

127. Shore J, Nalder E, Hutchison M, Reed N, Hunt A. Tele-Active Rehabilitation for Youth With Concussion: Evidence-Based and Theory-Informed Intervention Development. JMIR Pediatr Parent. 2022 Apr;5(2):e34822.

128. Shore J, Bernick A, Nalder E, Hutchison M, Reed N, Hunt A. Adolescent and parent experiences with Tele-Active Rehabilitation for concussion: an exploratory qualitative study. Brain Inj. 2022 Aug;1–9.

129. Reed N, Silverberg ND, Iaccarino MA, McCrea M, McCulloch KL, Panenka W, et al. Returning to Activity After a Concussion. Arch Phys Med Rehabil. 2019 Apr;100(4):789–91.

130. El Emam K, Buckeridge D, Tamblyn R, Neisa A, Jonker E, Verma A. The re-identification risk of Canadians from longitudinal demographics. BMC Med Inform Decis Mak. 2011 Jun;11:46.

131. El Emam K, Dankar FK, Issa R, Jonker E, Amyot D, Cogo E, et al. A globally optimal k-anonymity method for the de-identification of health data. J Am Med Inform Assoc. 2009;16(5):670–82.

132. El Emam K, Arbuckle L, Koru G, Eze B, Gaudette L, Neri E, et al. De-identification methods for open health data: the case of the Heritage Health Prize claims dataset. J Med Internet Res. 2012 Feb;14(1):e33.

133. Leddy JJ, Haider MN, Ellis M, Willer BS. Exercise is Medicine for Concussion. Curr Sports Med Rep. 2018 Aug;17(8):262–70.

134. Worley ML, O’Leary MC, Sackett JR, Schlader ZJ, Willer B, Leddy JJ, et al. Preliminary Evidence of Orthostatic Intolerance and Altered Cerebral Vascular Control Following Sport-Related Concussion. Front Neurol. 2021;12:620757.

135. Johnson BD, Sackett JR, Schlader ZJ, Leddy JJ. Attenuated Cardiovascular Responses to the Cold Pressor Test in Concussed Collegiate Athletes. J Athl Train. 2020 Feb;55(2):124–31.

136. Haider MN, Johnson BD, Horn EC, Leddy JJ, Wilber CG, Reed EL, et al. Blunted Cardiac Parasympathetic Activation in Student Athletes With a Remote History of Concussion: A Pilot Study. Front Neurol. 2020;11:547126.